Keywords
T cell-mediated autoimmune disorder
CD4 T cells
B-cell responses
Lamina propria
Proinflammatory cytokines
IL-15
How to Cite
Abstract
Introduction: Celiac disease, or celiac sprue, is a T cell-mediated autoimmune disorder of the small intestine triggered by ingesting dietary gluten products in genetically susceptible individuals. The pathologic mechanism involves an immune response targeting gluten peptides, leading to inflammation, villous atrophy, and malabsorption in the small intestine. This research is a significant step in understanding the mechanisms of how CD4+ T cell (white blood cells that are an essential part of the human immune system) responses against gluten can lead to autoreactive B-cell responses and tissue destruction mediated by intraepithelial cytotoxic T cells in the small intestine. Your work in this field is crucial in advancing our understanding and managing celiac disease.
It also discusses the overexpression of IL-15 on enterocytes in active celiac disease. This overexpression of IL-15 is believed to contribute to the pathogenesis of the condition by promoting the survival and activation of intraepithelial lymphocytes, leading to tissue damage.
It addresses challenges in understanding specific phenotypes of celiac disease, such as slow-responsive, potential, and seronegative forms. These forms of the disease present unique diagnostic and management challenges, often requiring a multidisciplinary approach for effective treatment.
Conclusion: The articles provide valuable insights into the cellular mechanisms underlying celiac disease, the immune responses involved, and the impact of gluten on intestinal cells. They also address the practical implications of this knowledge, such as the significance of dietary management in controlling the disease and preventing complications. This research empowers you, the reader, with actionable information that can make a real difference in the lives of those affected by celiac disease.
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