Keywords
Moderate Hypothermia
Normothermia
Cardiac Surgery
Coronary artery Bypass Grafting
Troponin I
Lactic Acid
How to Cite
Abstract
Introduction: In open heart surgery such as Coronary artery Bypass Grafting, valve repair or replacement, or some congenital heart disease, patients are connected to the Cardiopulmonary bypass machine [1]. The cardiopulmonary bypass machine pumps the blood around the body while the heart is stopped and provides a bloodless field during cardiac surgery. Since an extracorporeal circuit is incorporated into the patient, abnormal physiological events are observed during Cardiopulmonary bypass. These events include hemodilution, interstitial fluid accumulation, complement activation, and depression of the immune system. Cardiopulmonary bypass is associated with an acute phase reaction of protease cascades, leucocyte, and platelet activation, resulting in tissue injury [2, 3] and limited functional reserve. For many years, it was believed that Cardiopulmonary bypass under hypothermia is much safer. The main reason for “cooling body” is to protect the brain, heart, and organs during cardiopulmonary bypass by reducing the body's metabolic rate [4]. In recent years, many studies have shown that cardiopulmonary bypass under Normothermia has many more advantages than moderate hypothermia.
This study aimed to compare and examine which method has advantages in terms of clinical outcome, morbidity, and mortality.
Patients and Methods. Sixty patients scheduled for Coronary artery Bypass Grafting x 3 were selected and enrolled in this study.
Results: According to our study's primary variables (Troponin I, Lactic Acid) and secondary variables, Cardiopulmonary bypass in Normothermia is superior to Moderate Hypothermia in patients who underwent Coronary artery Bypass Grafting.
Conclusion: Based on our data and literature [15, 16, 17], we concluded that Cardiopulmonary bypass in Coronary artery Bypass Grafting under Normothermia has advantages vs. Moderate Hypothermia. Troponin I and Lactic Acid are very good biomarkers that show us if heart and organ perfusion/protection is adequate during this procedure.
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