Small Cell Lung Cancer in a Young, Non-Smoker Patient
AJTES Volume 8, Number 2, July 2024
Nikolla J. et al - Small Cell Lung Cancer in a Young, Non-Smoker Patient.

Keywords

small cell lung cancer
computed tomography
lungs
histologic examination

How to Cite

Nikolla, J., Xhemalaj, D., Dhima, A., & Bega, D. (2024). Small Cell Lung Cancer in a Young, Non-Smoker Patient. Albanian Journal of Trauma and Emergency Surgery, 8(2), 1539-1542. https://doi.org/10.32391/ajtes.v8i2.395

Abstract

Introduction: A single lung nodule (SPN) is defined as a solitary lung opacification less than 3 cm in size. In particular, small cell lung cancer (SCLC) affects more patients, older and heavy smokers. A contrast-enhanced computed tomography of the chest followed by a f-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and the pathology examinations are the main ones that determine the diagnosis.

Case Report: A young patient, 33 years old, a non-smoking male mining engineer, presented to the clinic with a dry cough that started after a viral situation. No other known comorbidities and family history of lung cancer. A routine chest x-ray was ordered, where an apical round opacity in the apex of the right lung was seen. Sputum for mycobacterium tuberculosis was done and came back negative. A chest scan with contrast showed a solitary pulmonary nodule in the apex of the right lung with well-demarcated contours with dimensions 28 x 22 mm. Given that the dimensions of the nodule were large and not specific for benign pathology, a PET/CT was ordered, which confirmed the nodule resulted in an SUV over that 4.5, which was also not specific for lung TB. The histologic examination of the nodule was done then, and the result, unfortunately, was a small cell lung cancer in the right lung.

Conclusion: SCLC is found to be a mass lesion in the lungs in most cases. Differential diagnosis between lung tuberculosis (TB) and lung cancer in such cases is an excellent dilemma for pulmonologists and radiologists.

https://doi.org/10.32391/ajtes.v8i2.395
Nikolla J. et al - Small Cell Lung Cancer in a Young, Non-Smoker Patient.

References

1. CM Mery et al. Relationship between a history of antecedent cancer and the probability of malignancy for a solitary pulmonary nodule Chest (2004)
2. MD Seemann et al. Differentiation of malignant from benign solitary pulmonary lesions using chest radiography, spiral CT, and HRCT Lung Cancer (2000)
3. Travis WD. Update on small cell carcinoma and its differentiation from squamous cell carcinoma and other non-small cell carcinomas. Mod Pathol. 2012 Jan;25 Suppl 1:S18-30.
4. Schneider B, Saxena A, Downey R. Surgery for Early-Stage Small Cell Lung Cancer. J Natl Compr Canc Netw. 2011;9(10):1132-9. doi:10.6004/jnccn.2011.0094
5. Wu L, Cao G, Zhao L, et al. Spectral CT Analysis of Solitary Pulmonary Nodules for Differentiating Malignancy from Benignancy: The Value of Iodine Concentration Spatial Distribution Difference. Biomed Res Int 2018; 2018: 4830659.
6. Singh SK, Ahmad Z, Bhargava R, Pandey DK, Gupta V, Garg PK. Coincidence of tuberculosis and malignancy: a diagnostic dilemma. South Med J. (2009) 102:113. doi: 10.1097/SMJ.0b013e318188e32c
7. Setio AAA, Traverso A, de Bel T, Berens MSN, Bogaard C van den, Cerello P, et al. Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge. Med Image Anal. (2017) 42:1–13. doi: 10.1016/j.media.2017.06.015
8. Vento S, Lanzafame M. Tuberculosis and cancer: a complex and dangerous liaison. Lancet Oncol. (2011) 12:520–2. doi: 10.1016/S1470-2045(11)70105-X
9. Quoix E, Fraser R, Wolkove N, Finkelstein H, Kreisman H. Small cell lung cancer presenting as a solitary pulmonary nodule. Cancer. 1990 Aug 1;66(3):577-82. doi: 10.1002/1097-0142(19900801)66:3<577: aid-cncr2820660328>3.0.co;2-y. PMID: 2163746
10. Global Burden of Disease Cancer Collaboration; Fitzmaurice C, Dicker D, et al. The Global Burden of Cancer 2013. JAMA Oncol 2015; 1:505-27. 10.1001/jamaoncol.2015.0735 [PMC free article] [PubMed] [CrossRef] [Google Scholar]
11. Siegel RL, Miller KD, Fuchs HE, et al. Cancer Statistics, 2021. CA Cancer J Clin 2021; 71:7-33. 10.3322/caac.21654
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