New Pathogens in Blood Donors and Patients in Albania
AJTES Vol 9, No 1, January 2025
Seferi I. et al. - New Pathogens in Blood Donors and Patients in Albania.

Keywords

Blood donors
Emerging pathogens
Blood safety
Transfusion medicine

How to Cite

Seferi, I., Shano, V., Dakavelli, B., Duro, V., Qyra, S., & Bulo, A. (2025). New Pathogens in Blood Donors and Patients in Albania. Albanian Journal of Trauma and Emergency Surgery, 9(1), 1630-1634. https://doi.org/10.32391/ajtes.v9i1.439

Abstract

Introduction: The emergence of novel pathogens poses a significant and immediate threat to global blood safety, particularly in regions experiencing epidemiological shifts. This study urgently examines the prevalence and impact of newly identified pathogens among blood donors and recipients in Albania, focusing on assessing their implications for public health and transfusion medicine.

Results revealed a prevalence of new pathogens among donors and patients, highlighting the potential risk of transmission through blood transfusion. Travel history, socioeconomic status, and urban-rural disparities significantly influenced pathogen prevalence. This study underscores the urgent need for enhanced screening protocols and public health interventions to mitigate the risks associated with emerging pathogens. Our findings contribute to a growing body of evidence emphasizing the crucial role of continuous surveillance and adaptive strategies in transfusion medicine to ensure blood safety and protect vulnerable populations in Albania and beyond.

Conclusion: The study highlights the presence of emerging pathogens in blood donors and patients in Albania, underscoring their potential to significantly impact blood safety and public health. The findings emphasize the necessity for improved screening protocols, continuous epidemiological surveillance, and targeted public health interventions to address the risks associated with these pathogens. Adopting adaptive strategies in transfusion medicine is critical to safeguarding the health of donors and recipients in the region.

https://doi.org/10.32391/ajtes.v9i1.439
Seferi I. et al. - New Pathogens in Blood Donors and Patients in Albania.

References

1. Wu, D., Feng, F., Wang, X. et al. The impact of nucleic acid testing to detect human immunodeficiency virus, hepatitis C virus, and hepatitis B virus yields from a single blood center in China with 10-years review. BMC Infect Dis 22, 279 (2022). https://doi.org/10.1186/s12879-022-07279-5

Luo, Y., & Qiu, J. (2015). Human parvovirus B19: a mechanistic overview of infection and DNA replication. Future virology, 10(2), 155–167. https://doi.org/10.2217/fvl.14.103

Juhl, D., & Hennig, H. (2018). Parvovirus B19: What Is the Relevance in Transfusion Medicine? Frontiers in medicine, 5, 4. https://doi.org/10.3389/fmed.2018.00004

Allen, P. D., Bustin, S. A., & Newland, A. C. (1993). The role of apoptosis (programmed cell death) in hemopoiesis and the immune system. Blood Reviews, 7(1), 63–73. https://doi.org/10.1016/0268-960x(93)90025-y

Brown, K. E., & Young, N. S. (1995). Parvovirus B19 infection and hematopoiesis. Blood reviews, 9(3), 176–182. https://doi.org/10.1016/0268-960x(95)90023-3

Rebouças, K. A. A. F., Narici, F. M., Santos Junior, M. N., Neres, N. S. M., Oliveira, M. V., & Souza, C. L. (2019). Seroprevalence of transfusion-transmissible infectious diseases at a hemotherapy service located in southwest Bahia, Brazil. Hematology, transfusion and cell therapy, 41(4), 324–328. https://doi.org/10.1016/j.htct.2019.03.007

Biggerstaff B. J. (2020). Estimation of time-dependent arbovirus infection risk in blood and tissue donations. Statistical communications in infectious diseases, 12(1), 10.1515/scid-2020-0001. https://doi.org/10.1515/scid-2020-0001

Erikstrup, C., Hother, C. E., Pedersen, O. B. V., Mølbak, K., Skov, R. L., Holm, D. K., Sækmose, S. G., Nilsson, A. C., Brooks, P. T., Boldsen, J. K., Mikkelsen, C., Gybel-Brask, M., Sørensen, E., Dinh, K. M., Mikkelsen, S., Møller, B. K., Haunstrup, T., Harritshøj, L., Jensen, B. A., Hjalgrim, H., … Ullum, H. (2021). Estimation of SARS-CoV-2 Infection Fatality Rate by Real-time Antibody Screening of Blood Donors. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 72(2), 249–253. https://doi.org/10.1093/cid/ciaa849

Carrasco, L., Utrilla, M. J., Fuentes-Romero, B., Fernandez-Novo, A., & Martin-Maldonado, B. (2024). West Nile Virus: An Update Focusing on Southern Europe. Microorganisms, 12(12), 2623. https://doi.org/10.3390/microorganisms12122623

Iqbal, H., Mehmood, B. F., Sohal, A., & Roytman, M. (2023). Hepatitis E infection: A review. World journal of virology, 12(5), 262–271. https://doi.org/10.5501/wjv.v12.i5.262

Wolski, A., Pischke, S., Ozga, A. K., Addo, M. M., & Horvatits, T. (2023). Higher Risk of HEV Transmission and Exposure among Blood Donors in Europe and Asia in Comparison to North America: A Meta-Analysis. Pathogens (Basel, Switzerland), 12(3), 425. https://doi.org/10.3390/pathogens12030425

Péron JM. Hepatitis E Virus Infection and Cirrhosis of the Liver. Gastroenterol Hepatol (N Y). 2016 Sep;12(9):565-567. PMID: 27917096; PMCID: PMC5114516.

Frankal, M., Skoglund, C., Castedal, M., Lagging, M., & Norder, H. (2022). Hepatitis E Virus Infection, a Risk for Liver Transplant Recipients in Sweden. Transplantation direct, 8(12), e1409. https://doi.org/10.1097/TXD.0000000000001409

Singson, S., Shastry, S., Sudheesh, N., Chawla, K., Madiyal, M., Kandasamy, D., & Mukhopadhyay, C. (2024). Assessment of Hepatitis E virus transmission risks: a comprehensive review of cases among blood transfusion recipients and blood donors. Infection ecology & epidemiology, 14(1), 2406834. https://doi.org/10.1080/20008686.2024.2406834

Amin Y. E. S., Abakur E. H. A., West Nile virus IgG antibodies among blood donors in Sudan: a cross-sectional study. 2022 Dec 5:49-50:101062. doi: 10.1016/j.nmni.2022.101062. eCollection 2022 Nov-Dec. DOI: 10.1016/j.nmni.2022.101062

Biggerstaff, B.J.& Peterson, L. R. (2002) Estimated risk of West Nile virus transmission through blood transfusion during an epidemic in Queens, New York City. Transfusion, 40,1019-1026.

Al-Sadeq, D. W., Majdalawieh, A. F., & Nasrallah, G. K. (2017). Seroprevalence and incidence of hepatitis E virus among blood donors: A review. Reviews in medical virology, 10.1002/rmv.1937. Advanced online publication. https://doi.org/10.1002/rmv.1937

Purcell R, Emerson S. Hepatitis E: an emerging awareness of an old disease. J Hepatol.2008:48(3):494-503

Pisani, G., Cristiano, K., Pupella, S., & Liumbruno, G. M. (2016). West Nile Virus in Europe and Safety of Blood Transfusion. Transfusion medicine and hemotherapy: offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 43(3), 158–167. https://doi.org/10.1159/000446219

Wenzel, J. J., Preiss, J., Schemmerer, M., Huber, B., & Jilg, W. (2013). Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. The Journal of Infectious Diseases, 207(3), 497–500. https://doi.org/10.1093/infdis/jis688

Kodani, M., Kamili, N. A., Tejada-Strop, A., Poe, A., Denniston, M. M., Drobeniuc, J., & Kamili, S. (2017). Variability in the performance characteristics of IgG anti-HEV assays and its impact on reliability of seroprevalence rates of hepatitis E. Journal of Medical Virology, 89(6), 1055–1061. https://doi.org/10.1002/jmv.24741

Rossi-Tamisier, M., Moal, V., Gerolami, R., & Colson, P. (2013). Discrepancy between anti-hepatitis E virus immunoglobulin G prevalence assessed by two assays in kidney and liver transplant recipients. Journal of Clinical Virology: the Official publication of the Pan American Society for Clinical Virology, 56(1), 62–64. https://doi.org/10.1016/j.jcv.2012.09.010

O'Bryan, T. A., & Wright, W. F. (2010). Parvovirus B19 and C-reactive protein in blood bank donors: implications for hygiene hypothesis research. Lupus, 19(13), 1557–1560. https://doi.org/10.1177/0961203310375438

Manaresi, E., Gallinella, G., Morselli Labate, A. M., Zucchelli, P., Zaccarelli, D., Ambretti, S., Delbarba, S., Zerbini, M., & Musiani, M. (2004). Seroprevalence of IgG against conformational and linear capsid antigens of parvovirus B19 in Italian blood donors. Epidemiology and infection, 132(5), 857–862. https://doi.org/10.1017/s0950268804002389

AABB Special Issue: Emerging Infectious Disease Agents and their Potential Threat to Transfusion Safety. Human Parvovirus B19.Transfusion 2009: 49:107S-9S.

Groeneveld, K., & van der Noordaa, J. (2003). Blood products and parvovirus B19. The Netherlands journal of medicine, 61(5), 154–156.

Juhl, D., Görg, S., & Hennig, H. (2014). Persistence of Parvovirus B19 (B19V) DNA and humoral immune response in B19V-infected blood donors. Vox sanguinis, 107(3), 226–232. https://doi.org/10.1111/vox.12162

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