Abstract
Background: The topic of artificial Intelligence and its application in medicine has gained tremendous popularity, coinciding with advances in its technology. Breast cancer treatments vary, with surgery being one of them.
In this review, we aim to evaluate artificial Intelligence’s ability to predict surgical outcomes, complications, and survival rates after breast cancer surgery by analyzing original research conducted over the last 5 years.
Materials and Methods: A PubMed search was conducted by two authors from January 1, 2020, to April 13, 2025, using the keywords "Artificial Intelligence" and "Breast Surgery". After elimination, 14 of the 215 articles were full-text screened, and nine original articles were selected for inclusion in our review.
Discussion: Artificial intelligence models and systems have had a significant impact on the medical field, and breast cancer surgery is no exception. Several original research studies have explored AI's ability to predict surgical outcomes and postoperative results. In this review, we focus on the postoperative aspects of breast cancer surgery and its application of artificial intelligence.
Of the nine articles included in this paper, all reported multiple statistically significant results (p <0.05). Although no prospective research directly compares artificial intelligence with practicing physicians, artificial intelligence’s ability to accurately predict surgical outcomes, complications, and survival has shown higher accuracy and c-index than commonly used prediction methods, as reported in multiple studies.
Conclusion: Artificial Intelligence can be a valuable asset in helping surgeons and medical doctors worldwide predict prognosis with improved systems and accuracy rates, even surpassing those of currently used conservative systems. There is a lack of information on PubMed regarding the comparison of these two aspects, particularly with larger sample sizes. More research should be conducted on this topic, particularly in comparing Artificial Intelligence systems and models with current systems and evaluation methods.
References
McCarthy, J., Minsky, M. L., Rochester, N., & Shannon, C. E. (1955). A proposal for the Dartmouth summer research project on Artificial Intelligence. Retrieved [February 15, 2025], from https://www-formal.stanford.edu/jmc/history/dartmouth/dartmouth.html
OpenAI. (2022). "Introducing ChatGPT." OpenAI, November 30, 2022. Retrieved [February 15, 2025], from https://openai.com/blog/chatgpt
International Agency for Research on Cancer. (2022). Global cancer statistics 2022. World Health Organization. Retrieved [February 15, 2025], from https://gco.iarc.fr/today/en/dataviz/bars?types=0_1&mode=cancer&group_populations=1&sort_by=value1&sexes=1_2
Chlebowski RT. Improving breast cancer risk assessment versus implementing breast cancer prevention. J Clin Oncol (2017) 35:702 4.
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-1474.
Haybittle TS, Blamey RW, Elston CW, et al. A prognostic index in primary breast cancer. Br J Cancer. 1982;46(3):361–366.
Amin MB, Edge S, Greene F, et al. AJCC Cancer Staging Manual. 8th ed. Springer; 2017.
Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004;351(27):2817-2826.
Buyse M, Loi S, van’t Veer L, et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. Lancet. 2006;368(9531):67-75.
Parker JS, Mullins M, Cheang MC, et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol. 2009;27(8):1160-1167.
Ravdin PM, Cronin KA, Klee GG, et al. Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Natl Cancer Inst. 2001;93(23):1802-1813.
Zeng L, Liu L, Chen D, Lu H, Xue Y, Bi H and Yang W (2023). The innovative model based on artificial intelligence algorithms to predict recurrence risk of patients with postoperative breast cancer. Front. Oncol. 13:1117420.
Son Y, Han K, Lee YS, Yu J, Im Y-H, Shin S-Y (2021). Privacy-preserving breast cancer recurrence prediction based on homomorphic encryption and secure two-party computation. PLoS ONE 16(12): e0260681
Gómez-Flores W, Coelho de Albuquerque Pereira W. A comparative study of pre-trained convolutional neural networks for semantic segmentation of breast tumors in ultrasound. Comput Biol Med. 2020 Nov;126:104036.
Veluponnar, D.; de Boer, L.L.; Geldof, F.; Jong, L.-J.S.; Da Silva Guimaraes, M.; Vrancken Peeters, M.-J.T.F.D.; van Duijnhoven, F.; Ruers, T.; Dashtbozorg, B. Toward Intraoperative Margin Assessment Using a Deep Learning-Based Approach for Automatic Tumor Segmentation in Breast Lumpectomy Ultrasound Images. Cancers 2023, 15, 1652.
Larson BJ, Roakes A, Yurick S, Netravali NA. Precision in Prevention: Tailoring Single-Use Negative Pressure Wound Therapy Utilization Through Artificial Intelligence-Based Surgical Site Complications Risk and Cost Modeling. Surg Infect (Larchmt). 2024 May;25(4):315-321.
Saturno MP, Mejia MR, Wang A, Kwon D, Oleru O, Seyidova N, Henderson PW. Generative artificial Intelligence fails to provide sufficiently accurate recommendations when compared to established guidelines for breast reconstruction surgery. J Plast Reconstr Aesthet Surg.
Xu W, Wang X, Yang L, Meng M, Sun C, Li W, Li J, Zheng L, Tang T, Jia W, Chen X. Consistency of CSCO AI with Multidisciplinary Clinical Decision-Making Teams in Breast Cancer: A Retrospective Study. Breast Cancer (Dove Med Press). 2024 Jul 29;16:413-422.
Yu Y, Ren W, He Z, Chen Y, Tan Y, Mao L, Ouyang W, Lu N, Ouyang J, Chen K, Li C, Zhang R, Wu Z, Su F, Wang Z, Hu Q, Xie C, Yao H. Machine learning radiomics of magnetic resonance imaging predicts recurrence-free survival after surgery and correlation of LncRNAs in patients with breast cancer: a multicenter cohort study. Breast Cancer Res. 2023 November 1;25(1):132.
Ma J, Chen K, Li S, Zhu L, Yu Y, Li J, Ma J, Ouyang J, Wu Z, Tan Y, He Z, Liu H, Pan Z, Li H, Liu Q, Song E. MRI-based radiomic models to predict surgical margin status and infer tumor immune microenvironment in breast cancer patients with breast-conserving surgery: a multicenter validation study. Eur Radiol.
