From Skin to Mind: Psoriasis and Its Psychological Burden.
AJTES Vol 10, No. 2, July 2026
Muja D. & Vasili E. - Psoriasis: Psychological and Clinical Burden

Keywords

Psoriasis
Depression
Psychodermatology
Quality of life
Methotrexate
Multidisciplinary care

How to Cite

Muja, D., & Vasili, E. (2026). From Skin to Mind: Psoriasis and Its Psychological Burden. Albanian Journal of Trauma and Emergency Surgery, 10(2), 2176-2180. https://doi.org/10.32391/ajtes.v10i2.531

Abstract

Background: Psoriasis is a persistent immune-driven skin disease shaped by environmental and psychological triggers like infections, stress, and climate. Beyond its physical toll, psoriasis deeply disrupts daily life, straining social connections, family bonds, and professional pursuits. Psychiatric conditions, particularly depression, frequently accompany it, affecting up to 30% of patients.

Case Report: We share the story of a 24-year-old woman battling chronic plaque psoriasis, whose condition resisted topical treatments and led to deepening depression. Through a collaborative approach blending dermatological care and psychiatric support, including systemic methotrexate and antidepressants, she experienced remarkable progress both physically and emotionally.

Conclusions: This case powerfully illustrates the heavy psychological weight carried by those with chronic plaque psoriasis. It calls attention to the urgent need for integrated dermatological and mental health care, ensuring patients receive truly comprehensive support.

https://doi.org/10.32391/ajtes.v10i2.531
Muja D. & Vasili E. - Psoriasis: Psychological and Clinical Burden

References

Man, A. M., Orăsan, M. S., Hoteiuc, O. A., Olănescu-Vaida-Voevod, M. C., & Mocan, T. (2023). Inflammation and Psoriasis: A Comprehensive Review. International journal of molecular sciences, 24(22), 16095. https://doi.org/10.3390/ijms242216095

Che Awanis, C. J., Norhayati, M. N., & Mat Yudin, Z. (2026). Beyond the skin: Lived experiences and coping strategies of psoriasis patients in Malaysia. PloS one, 21(1), e0329066. https://doi.org/10.1371/journal.pone.0329066

Ponikowska, M., Vellone, E., Czapla, M., & Uchmanowicz, I. (2025). Challenges Psoriasis and Its Impact on Quality of Life: Challenges in Treatment and Management. Psoriasis (Auckland, N.Z.), 15, 175–183. https://doi.org/10.2147/PTT.S519420

Nazik, H., Nazik, S., & Gul, F. C. (2017). Body Image, Self-esteem, and Quality of Life in Patients with Psoriasis. Indian dermatology online journal, 8(5), 343–346. https://doi.org/10.4103/idoj.IDOJ_503_15

Michalek, I. M., Loring, B., & John, S. M. (2017). A systematic review of worldwide epidemiology of psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV, 31(2), 205–212. https://doi.org/10.1111/jdv.13854

Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E., & Barker, J. N. W. N. (2021). Psoriasis. Lancet (London, England), 397(10281), 1301–1315. https://doi.org/10.1016/S0140-6736(20)32549-6

Rendon, A., & Schäkel, K. (2019). Psoriasis Pathogenesis and Treatment. International journal of molecular sciences, 20(6), 1475. https://doi.org/10.3390/ijms20061475

Magin, P., Adams, J., Heading, G., Pond, D., & Smith, W. (2009). The psychological sequelae of psoriasis: results of a qualitative study. Psychology, health & medicine, 14(2), 150–161. https://doi.org/10.1080/13548500802512294

Sampogna, F., Tabolli, S., Abeni, D., & IDI Multipurpose Psoriasis Research on Vital Experiences (IMPROVE) investigators (2012). Living with psoriasis: prevalence of shame, anger, worry, and problems in daily activities and social life. Acta dermato-venereologica, 92(3), 299–303. https://doi.org/10.2340/00015555-1273

Russo, P. A., Ilchef, R., & Cooper, A. J. (2004). Psychiatric morbidity in psoriasis: a review. The Australasian journal of dermatology, 45(3), 155–161. https://doi.org/10.1111/j.1440-0960.2004.00078.x

Zięciak, T., Rzepa, T., Król, J., & Żaba, R. (2017). Stigmatization feelings and depression symptoms in psoriasis patients. Poczucie stygmatyzacji a objawy depresyjne u osób chorych na łuszczycę. Psychiatria polska, 51(6), 1153–1163. https://doi.org/10.12740/PP/68848

Beretta, L., Cossu, M., Marchini, M., Cappiello, F., Artoni, A., Motta, G., & Scorza, R. (2008). A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation. Arthritis research & therapy, 10(5), R103. https://doi.org/10.1186/ar2495

Lim DS, Bewley A, Oon HH. Psychological profile of patients with psoriasis. Ann Acad Med Singapore. 2018;47(12):516–22.

Rompoti, N., Tsiori, S., Kontoangelos, K., Kouzoupis, A., Papageorgiou, C., Gregoriou, S., Stratigos, A., & Rigopoulos, D. (2024). Psychopathological Profile of Patients with Moderate-to-Severe Plaque Psoriasis and Its Correlation to DLQI: Results from a Prospective, Monocentric Clinical Study. Journal of Clinical Medicine, 13(21), 6424. https://doi.org/10.3390/jcm13216424

Copyright (c) 2026 Diana Muja, Ermira Vasili