Measures of Risk for Sepsis and Mortality in Severe Burned Patients with Stress Induced Hyperglycemia.
AJTES Vol. 5, No 2, July 2021.
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Aleksi, A., & Belba, M. (2021). Measures of Risk for Sepsis and Mortality in Severe Burned Patients with Stress Induced Hyperglycemia. Albanian Journal of Trauma and Emergency Surgery, 5(2), 830-833.


Background; Hyperglycemia as a medical condition due to diabetes or other underlying conditions like Stress-Induced Hyperglycemia and sepsis as a life-threatening medical condition are two of the challenges faced during burn treatment.

The purpose of this study was to evaluate the risk for sepsis and mortality for the patients with critical hyperglycemic values during the disease.

Material and Methods; This is an observational retrospective cohort study conducted in the Service of Burns of the University Hospital Centre “Mother Teresa” in Tirana (UHCT), Albania from 1st January 2010 to 31st December 2014. Patients were categorized as having euglycemia (mean BG values ranging from 80-120 mg/dl), moderate hyper Sepsis was defined according to the ABA Consensus Panel Publication for Infection and Sepsis glycemia (mean BG values <180 mg/dl) or critical hyperglycemia (mean BG values ≥180 mg/dl). to evaluate the impact of the presence of critical hyperglycemia during the disease in sepsis and mortality, we performed Relative risk, Odds ratio

Results; Those who had overall hyperglycemia (Moderate and Critical) had 2.6 times the risk for sepsis compared to those who were in the euglycemia group. Analyzing the risk of mortality in patients with overall hyperglycemia during the disease, we observed that the chance of a bad outcome was 2.7 times more likely to occur if the patient had hyperglycemia (RR=2.7).

Conclusions: Glucose values on admission, as one of the derangement features of burn shock, are prognostic factors in critical hyperglycemia during burn disease and have a close relationship with other outcomes (sepsis and mortality).
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Mizock BA: Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab, 15: 533-551, 2001.

Van den Berghe G, Wouters P, Weekers F, Verwaest Ch et al.: Intensive insulin therapy in critically ill patients. N Engl J Med, 345: 1359-1367, 2001.

Greenhalgh DG, Saffle JR, Holmes JH 4th et al.: American Burn Association Consensus Conference on Burn Sepsis and Infection Group. J Burn Care Res, 28: 776-90, 2007.

Egi M, Bellomo R, Stachowski E et al.: Blood glucose concentration and outcome of critical illness: the impact of diabetes. Critical Care Medicine, 36(8): 2249-55, 2008.

Duncan AE: Hyperglycaemia and Perioperative Glucose Management. Curr Pharm Des, 18(38): 6195-6203, 2012.

Duncan AE, Abd-Elsayed A, Maheshwari A, Xu M et al.: Role of intraoperative and postoperative blood glucose concentrations in predicting outcomes after cardiac surgery. Anesthesiology, 112(4): 860-71, 2010.

Meccott GA, Al -Mousawi AM, Gauglitz GG, Herndon DN, Jeschke MG: The role of hyperglycaemia in burned patients: Evidence-based studies. Shock, 33(1): 5-13, 2010.

Cree MG, Aarsland A, Herndon DN et al.: Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance. Crit Care Med, 35: S476-83, 2007.

Pidcoke HF, Wade Ch E, Wolf SE: Insulin and the burned patient. Crit Care Med, 35 (9) (Suppl.): S524-S530, 2007.

Gauglitz GG, Halder S, Boehning DF, Kulp GA et al.: Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress. Shock, 33: 299-305, 2010.

Jeschke MG, Kraft R, Song J, Gauglitz GG et al.: Insulin protects against hepatic damage postburn. Mol Med, 17: 516-522, 2011.

Pereira CT, Murphy KD, Herndon DN: Altering metabolism. J Burn Care Rehabil, 26: 194-199, 2005.

Gore DC, Chinkes D, Heggers J, Herndon DN et al.: Association of hyperglycaemia with increased mortality after severe burn injury. J Trauma, 51(3): 540-544, 2001.

Umpierrez GE, Isaacs SD, Bazargan N, You X et al.: Hyperglycaemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab, 87(3): 978-82, 2002.

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