Survival Predictors of Preterm Neonates, Single-Center Experience.
AJTES Vol. 5, No 2, July 2021.
Full text

Keywords

Preterm Birth
Neonatal
Intensive Care
born prematurely

How to Cite

Dizdar, S., Mišanović, V., Gojak, R., Terzić, S., Anić, D., Maksić, H., Mrkulić, E., Begić, Z., Lenjani, B., & Ljuhar, K. (2021). Survival Predictors of Preterm Neonates, Single-Center Experience. Albanian Journal of Trauma and Emergency Surgery, 5(2), 859-863. https://doi.org/10.32391/ajtes.v5i2.246

Abstract

Introduction: Adequate prenatal and postnatal care for preterm neonates not only affects the survival rate, but also the occurrence of chronic diseases, and in the future also affects the quality of life of that children.

Aim: To examine the influence of independent predictors (weeks of gestation, body weight, sex) on the outcome of the disease and to analyze the influence of the applied ventilatory mode on the final outcome of treatment.

Material and methods:  The study included neonates (n = 248) born prematurely who were treated in the neonatal intensive care unit for a period of one year due to immaturity-related difficulties.

Results: The mean age of male neonates (n = 119) at birth was 31.13 ± 3.3 weeks of gestation (WG), and females (n = 129) 31.59 ± 3.2 WG. Weeks of gestation have a statistically significant effect on survival (p = 0.0001), for each more week of gestation, the chances of survival increase by 21%. There was no significant difference between birth weight and sex (p = 0.289), and the birth weight of the neonates had a statistically significant effect on survival (p = 0.0001). For every 10 grams of body weight, in our sample, the chance of survival increases by 2%. Ventilation mode showed a statistically significant effect on neonatal survival (p < 0.05), and intubation mode was used as an indicator. If neonates are switched from non-invasive to invasive ventilation mode, the chance of survival in our sample is reduced by 88%.

Conclusion: Weeks of gestation, birth weight, and the use of a noninvasive mode of ventilation are predictors of a positive outcome for preterm neonates.

https://doi.org/10.32391/ajtes.v5i2.246
Full text

References

1. Kelly MM. The basics of prematurity. J Pediatr Health Care. 2006 Jul-Aug;20(4):238-44. doi: 10.1016/j.pedhc.2006.01.001.
2. Harrison MS, Goldenberg RL. Global burden of prematurity. Semin Fetal Neonatal Med. 2016 Apr;21(2):74-9. doi: 10.1016/j.siny.2015.12.007.
3. Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ. Outcomes for extremely premature infants. Anesth Analg. 2015;120(6):1337-1351. doi:10.1213/ANE.0000000000000705
4. Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012 Jun 9;379(9832):2162-72. doi: 10.1016/S0140-6736(12)60820-4.
5. Field DJ, Dorling JS, Manktelow BN, Draper ES. Survival of extremely premature babies in a geographically defined population: prospective cohort study of 1994-9 compared with 2000-5. BMJ. 2008 May 31;336(7655):1221-3. doi: 10.1136/bmj.39555.670718.BE.
6. Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK; NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007 Feb;196(2):147.e1-8. doi: 10.1016/j.ajog.2006.09.014.
7. Zeitlin J, Ancel PY, Delmas D, Bréart G, Papiernik E; EPIPAGE and MOSAIC Ile-de-France Groups. Changes in care and outcome of very preterm babies in the Parisian region between 1998 and 2003. Arch Dis Child Fetal Neonatal Ed. 2010 May;95(3):F188-93. doi: 10.1136/adc.2008.156745.
8. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008 Jan 5;371(9606):75-84. doi: 10.1016/S0140-6736(08)60074-4. PMID: 18177778; PMCID: PMC7134569.
9. Medjedovic E, Kurjak A. Doppler ultrasonography of the uterine artery in correlation with KANET. J Perinat Med. 2020 Dec 22:jpm-2020-0544. doi: 10.1515/jpm-2020-0544.
10. Watkis Wj, Kotecha SJ, Kotecha S. All- Cause Mortality of Low Birthweight Infants in Infancy, Childhood, and Adolescence: Population Study of England and Wales.PloSMed 2016; 13:e1002018.
11. Infant Mortality Rate for Bosnia and Herzegovina. URL: https://alfred.stlouisfed.org/series?seid=SPDYNIMRTINBIH&utm_source=series_page&utm_medium=related_content&utm_term=related_resources&utm_campaign=alfred (retrieved March 10, 2021)
12. Patel RM, Kandefer S, Walsh MC, Bell EF, Carlo WA, Laptook AR, Sánchez PJ, Shankaran S, Van Meurs KP, Ball MB, Hale EC, Newman NS, Das A, Higgins RD, Stoll BJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Causes and timing of death in extremely premature infants from 2000 through 2011. N Engl J Med. 2015 Jan 22;372(4):331-40. doi: 10.1056/NEJMoa1403489.
13. Norman M, Hallberg B, Abrahamsson T, Björklund LJ, Domellöf M, Farooqi A, Foyn Bruun C, Gadsbøll C, Hellström-Westas L, Ingemansson F, Källén K, Ley D, Maršál K, Normann E, Serenius F, Stephansson O, Stigson L, Um-Bergström P, Håkansson S. Association Between Year of Birth and 1-Year Survival Among Extremely Preterm Infants in Sweden During 2004-2007 and 2014-2016. JAMA. 2019 Mar 26;321(12):1188-1199. doi: 10.1001/jama.2019.2021.
14. Zeitlin J, El Ayoubi M, Jarreau PH, Draper ES, Blondel B, Künzel W, Cuttini M, Kaminski M, Gortner L, Van Reempts P, Kollée L, Papiernik E; MOSAIC Research Group. Impact of fetal growth restriction on mortality and morbidity in a very preterm birth cohort. J Pediatr. 2010 Nov;157(5):733-9.e1. doi: 10.1016/j.jpeds.2010.05.002.
15. Kent AL, Wright IM, Abdel-Latif ME; New South Wales and Australian Capital Territory Neonatal Intensive Care Units Audit Group. Mortality and adverse neurologic outcomes are greater in preterm male infants. Pediatrics. 2012 Jan;129(1):124-31. doi: 10.1542/peds.2011-1578.
16. Garfinkle J, Yoon EW, Alvaro R, Nwaesei C, Claveau M, Lee SK, Shah PS; Canadian Neonatal Network Investigators. Trends in sex-specific differences in outcomes in extreme preterms: progress or natural barriers? Arch Dis Child Fetal Neonatal Ed. 2020 Mar;105(2):158-163. doi: 10.1136/archdischild-2018-316399.
17. Neto RM, Ramos JGL, Medjedovic E, Begic E. Increased of the carotid intima media thickness in preeclampsia. J Perinat Med. 2020 Oct 25;48(8):787-791. doi: 10.1515/jpm-2020-0158.
18. Oskovi Kaplan ZA, Ozgu-Erdinc AS. Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview. J Pregnancy. 2018; 2018: 8367571. doi:10.1155/2018/8367571
19. Hughes K, Sim S, Roman A, Michalak K, Kane S, Sheehan P. Outcomes and predictive tests from a dedicated specialist clinic for women at high risk of preterm labour: A ten-year audit. Aust N Z J Obstet Gynaecol. 2017 Aug;57(4):405-411. doi: 10.1111/ajo.12610.
20. Krupa FG, Faltin D, Cecatti JG, Surita FG, Souza JP. Predictors of preterm birth. Int J Gynaecol Obstet. 2006 Jul;94(1):5-11. doi: 10.1016/j.ijgo.2006.03.022.
21. TROSHANI, A., & VEVECKA, E. (2020). The Impact of Timing of Elective Cesarean Delivery at Term in Neonatal Respiratory Morbidity. Albanian Journal of Trauma and Emergency Surgery, 4(2), 653 - 660. https://doi.org/10.32391/ajtes.v4i2.93
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.