Morphological Aspects and Treatment Strategies for Chronic Total Occlusions of the Coronary Arteries.
Fagu a et al. - Morphological Aspects and Treatment Strategies for Chronic Total Occlusions of the Coronary Arteries.

Keywords

Chronic total occlusions
Coronary artery disease
CTO
CABG
CTO-PCI

How to Cite

Fagu, A., Shurdha, O., Caushi, N., Menkshi, K., Hasi, D., & Siqeca, M. (2023). Morphological Aspects and Treatment Strategies for Chronic Total Occlusions of the Coronary Arteries. Albanian Journal of Trauma and Emergency Surgery, 7(1), 1174-1180. https://doi.org/10.32391/ajtes.v7i1.295

Abstract

Coronary total occlusions are routinely found in patients suffering from chronic coronary artery disease. Their prevalence is between 20-50% and is higher in patients with prior coronary artery bypass surgery.  Patients with CTOs have a higher risk profile, higher Syntax scores and in approximately 80% of the cases, a multi-vessel disease. Advances in technology that supports CTO-PCI and the increasing operator experience in high volume centers has raised important questions about the revascularization strategy.  In the majority of cases, the treatment strategy for this group of patients should aim at achieving full revascularization. In this context CABG should be considered the first choice and percutaneous coronary intervention can be considered for patients with less advanced disease. It is not clear, whether successful CTO revascularization (CABG or PCI) have an impact on long-term outcomes. For these reasons, the treatment of patients in the presence of CTOs should be based on the current evidence on the treatment of multivessel coronary disease.

https://doi.org/10.32391/ajtes.v7i1.295
Fagu a et al. - Morphological Aspects and Treatment Strategies for Chronic Total Occlusions of the Coronary Arteries.

References

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association. Circulation. 2017 Jan 1;

Wilkins E, Wilson L, Wickramasinghe K, Bhatnagar P, Leal J, Luengo-Fernandez R, et al. European Cardiovascular Disease Statistics 2017 edition. European Heart Network, Brussels. 2017;192.

Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W, et al. A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis. Circulation [Internet]. 1995 Sep 1 [cited 2022 Sep 11];92(5):1355–74. Available from: https://www.ahajournals.org/doi/abs/10.1161/01.CIR.92.5.1355

Mario C Di, Werner GS, Sianos G, Galassi AR, Büttner J, Dudek D, et al. European perspective in the recanalisation of Chronic Total Occlusions (CTO): consensus document from the EuroCTO Club. EuroIntervention. 22AD May;3(1):30–43.

Maseri A, Chierchia S, Davies G. Pathophysiology of coronary occlusion in acute infarction. Circulation. 1986;73(2):233–9.

Galassi AR, Werner GS, Boukhris M, Azzalini L, Mashayekhi K, Carlino M, et al. Percutaneous recanalisation of chronic total occlusions: 2019 consensus document from the EuroCTO Club. EuroIntervention. 2019 Jun;15(2):198–208.

Bardají A, Rodriguez-López J, Torres-Sánchez M. Chronic total occlusion: To treat or not to treat. World J Cardiol. 2014 Jul 26;6(7):621–9.

Christofferson RD, Lehmann KG, Martin G v., Every N, Caldwell JH, Kapadia SR. Effect of chronic total coronary occlusion on treatment strategy. American Journal of Cardiology [Internet]. 2005 May 1 [cited 2021 Jan 5];95(9):1088–91. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0002914905001906

Jeroudi OM, Alomar ME, Michael TT, Sabbagh A el, Patel VG, Mogabgab O, et al. Prevalence and management of coronary chronic total occlusions in a tertiary veterans affairs hospital. Catheterization and Cardiovascular Interventions [Internet]. 2014 Oct 1 [cited 2021 Mar 23];84(4):637–43. Available from: https://pubmed.ncbi.nlm.nih.gov/24142769/

Fefer P, Knudtson ML, Cheema AN, Galbraith PD, Osherov AB, Yalonetsky S, et al. Current perspectives on coronary chronic total occlusions: The Canadian multicenter chronic total occlusions registry. J Am Coll Cardiol [Internet]. 2012 Mar 13 [cited 2021 Mar 23];59(11):991–7. Available from: http://dx.doi.org/10.1016/j.jacc.2011.12.007

Sousa-Uva M, Neumann FJ, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. European Journal of Cardio-thoracic Surgery [Internet]. 2019 Jan 1 [cited 2020 Nov 8];55(1):4–90. Available from: https://academic.oup.com/ejcts/article/55/1/4/5079878

Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease. New England Journal of Medicine. 2009 Mar 5;360(10):961–72.

Tajti P, Brilakis ES. Chronic total occlusion percutaneous coronary intervention: Evidence and controversies. J Am Heart Assoc. 2018;7(2):1–15.

Serruvs PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. New England Journal of Medicine. 2009 Mar 5;360(10):961–72.

Zakkar M, George SJ, Ascione R. Should chronic total occlusion be treated with coronary artery bypass grafting? Chronic total occlusion should be treated with coronary artery bypass grafting. Circulation. 2016;133(18):1807–16.

Toma A, Stähli BE, Gick M, Colmsee H, Gebhard C, Mashayekhi K, et al. Long-Term Follow-Up of Patients with Previous Coronary Artery Bypass Grafting Undergoing Percutaneous Coronary Intervention for Chronic Total Occlusion. American Journal of Cardiology [Internet]. 2016;118(11):1641–6. Available from: http://dx.doi.org/10.1016/j.amjcard.2016.08.038

Brilakis ES, Banerjee S, Karmpaliotis D, Lombardi WL, Tsai TT, Shunk KA, et al. Procedural outcomes of chronic total occlusion percutaneous coronary intervention: A report from the NCDR (National Cardiovascular Data Registry). JACC Cardiovasc Interv. 2015 Feb 1;8(2):245–53.

Winter MP, Goliasch G, Bartko P, Siller-Matula J, Ayoub M, Aschauer S, et al. Left Main Coronary Artery Disease and Outcomes after Percutaneous Coronary Intervention for Chronic Total Occlusions. J Clin Med. 2020 Mar 30;9(4):938.

Kahn JK. Angiographic suitability for catheter revascularization of total coronary occlusions in patients from a community hospital setting. Am Heart J. 1993 Sep 1;126(3 PART 1):561–4.

Toma A, Stähli BE, Gick M, Gebhard C, Kaufmann BA, Mashayekhi K, et al. Comparison of Benefit of Successful Percutaneous Coronary Intervention for Chronic Total Occlusion in Patients with Versus Without Reduced (≤40%) Left Ventricular Ejection Fraction. American Journal of Cardiology. 2017 Nov 15;120(10):1780–6.

Tsai TT, Stanislawski MA, Shunk KA, Armstrong EJ, Grunwald GK, Schob AH, et al. Contemporary Incidence, Management, and Long-Term Outcomes of Percutaneous Coronary Interventions for Chronic Coronary Artery Total Occlusions: Insights from the VA CART Program. JACC Cardiovasc Interv. 2017 May 8;10(9):866–75.

HASEGAWA T, GODINO C, BASAVARAJAIAH S, TAKAGI K, REZQ A, LATIB A, et al. Differences in the Clinical and Angiographic Characteristics of Chronic Total Occlusion Lesions in the Three Major Coronary Arteries. J Interv Cardiol [Internet]. 2014 Feb 1 [cited 2021 Feb 22];27(1):44–9. Available from: http://doi.wiley.com/10.1111/joic.12085

Lee SW, Lee PH, Ahn JM, Park DW, Yun SC, Han S, et al. Randomized Trial Evaluating Percutaneous Coronary Intervention for the Treatment of Chronic Total Occlusion: The DECISION-CTO Trial. Circulation [Internet]. 2019 Apr 2 [cited 2021 Mar 1];139(14):1674–83. Available from: http://ahajournals.org

Kandzari DE, Kini AS, Karmpaliotis D, Moses JW, Tummala PE, Grantham JA, et al. Safety and effectiveness of everolimus-eluting stents in chronic total coronary occlusion revascularization: Results from the EXPERT CTO multicenter trial (evaluation of the XIENCE coronary stent, performance, and technique in chronic total occlusions). JACC Cardiovasc Interv. 2015 May 1;8(6):761–9.

Werner GS, Martin-Yuste V, Hildick-Smith D, Boudou N, Sianos G, Gelev V, et al. A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions. Eur Heart J [Internet]. 2018 Jul 7 [cited 2021 Jan 4];39(26):2484–93. Available from: https://pubmed.ncbi.nlm.nih.gov/29722796/

Morino Y, Abe M, Morimoto T, Kimura T, Hayashi Y, Muramatsu T, et al. Predicting successful guidewire crossing through chronic total occlusion of native coronary lesions within 30 minutes: The J-CTO (Multicenter CTO Registry in Japan) score as a difficulty grading and time assessment tool. JACC Cardiovasc Interv [Internet]. 2011 Feb [cited 2022 Sep 12];4(2):213–21. Available from: https://pubmed.ncbi.nlm.nih.gov/21349461/

Seiler C, Stoller M, Pitt B, Meier P. The human coronary collateral circulation: Development and clinical importance. Eur Heart J. 2013;34(34):2674–82.

Pitt B. Interarterial Coronary Anastomoses Occurrence in Normal Heart and in Certain Pathologic Conditions. Circulation. 1959; XX(November):816–22.

Seiler C. Collateral Circulation of the Heart. Springer-Verlag London; 2009. 235–303 p.

Azzalini L, Torregrossa G, Puskas JD, Brilakis ES, Lombardi WL, Karmpaliotis D, et al. Percutaneous revascularization of chronic total occlusions: Rationale, indications, techniques, and the cardiac surgeon’s point of view. Int J Cardiol. 2017;

Werner GS. The role of coronary collaterals in chronic total occlusions. Curr Cardiol Rev. 2014;10(1).

Wijns W, Vatner SF, Camici PG. Mechanisms of disease: Hibernating myocardium. New England Journal of Medicine. 1998;339(3).

Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: A meta-analysis. J Am Coll Cardiol. 2002 Apr 3;39(7):1151–8.

Beanlands RSB, Nichol G, Huszti E, Humen D, Racine N, Freeman M, et al. F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients with Severe Left Ventricular Dysfunction and Suspected Coronary Disease. A Randomized, Controlled Trial (PARR-2). J Am Coll Cardiol. 2007 Nov 13;50(20):2002–12.

Zakkar M, George SJ, Ascione R. Should chronic total occlusion be treated with coronary artery bypass grafting? Chronic total occlusion should be treated with coronary artery bypass grafting. Circulation. 2016;133(18):1807–16.

Zakkar M, George SJ, Ascione R, Weintraub WS, Garratt KN. Should chronic total occlusion be treated with coronary artery bypass grafting? Chronic total occlusion should be treated with coronary artery bypass grafting. Circulation. 2016 May 3;133(18):1807–16.

Weintraub WS, Garratt KN. Should Chronic Total Occlusion Be Treated with Coronary Artery Bypass Grafting? Circulation. 2016;133(18):1818–25.

Mäkikallio T, Holm NR, Lindsay M, Spence MS, Erglis A, Menown IBA, et al. Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial. The Lancet [Internet]. 2016 Dec 3 [cited 2020 Oct 26];388(10061):2743–52. Available from: http://www.thelancet.com/article/S0140673616320529/fulltext

Sundt TM, Camillo CJ, Mendeloff EN, Barner HB, Gay WA. Reappraisal of coronary endarterectomy for the treatment of diffuse coronary artery disease. In: Annals of Thoracic Surgery. Elsevier; 1999. p. 1272–7.

Ghatanatti R, Teli A. Coronary endarterectomy: Recent trends. Vol. 11, Journal of Clinical and Diagnostic Research. Journal of Clinical and Diagnostic Research; 2017. p. PE01–4.

Gill IS, Beanlands DS, Boyd WD, Finlay S, Keon WJ. Left anterior descending endarterectomy and internal thoracic artery bypass for diffuse coronary disease. Annals of Thoracic Surgery. 1998 Mar;65(3):659–62.

Brewer R, Theurer PF, Cogan CM, Bell GF, Prager RL, Paone G. Morbidity but not mortality is decreased after off-pump coronary artery bypass surgery. Ann Thorac Surg [Internet]. 2014 Mar [cited 2022 Sep 13];97(3):831–6. Available from: https://pubmed.ncbi.nlm.nih.gov/24200395/

Bowdish ME, D’Agostino RS, Thourani VH, Desai N, Shahian DM, Fernandez FG, et al. The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2020 Update on Outcomes and Research. Ann Thorac Surg [Internet]. 2020 Jun 1 [cited 2022 Jan 13];109(6):1646–55. Available from: http://www.annalsthoracicsurgery.org/article/S0003497520304264/fulltext

Jang Y, Won H. History of CTO Intervention and Benefits of CTO PCI. In: Percutaneous Coronary Interventions for Chronic Total Occlusion [Internet]. Singapore: Springer Singapore; 2019 [cited 2021 Mar 13]. p. 1–7. Available from: http://link.springer.com/10.1007/978-981-10-6026-7_1

Stergiopoulos K, Boden WE, Hartigan P, Möbius-Winkler S, Hambrecht R, Hueb W, et al. Percutaneous coronary intervention outcomes in patients with stable obstructive coronary artery disease and myocardial ischemia: a collaborative meta-analysis of contemporary randomized clinical trials. JAMA Intern Med [Internet]. 2014 Feb [cited 2022 Sep 13];174(2):232–40. Available from: https://pubmed.ncbi.nlm.nih.gov/24296791/

Valenti R, Vergara R, Migliorini A, Parodi G, Buonamici P, Cerisano G, et al. Comparison of everolimus-eluting stent with paclitaxel-eluting stent in long chronic total occlusions. Am J Cardiol [Internet]. 2011 Jun 15 [cited 2022 Sep 13];107(12):1768–71. Available from: https://pubmed.ncbi.nlm.nih.gov/21529743/

Valenti R, Vergara R, Migliorini A, Parodi G, Carrabba N, Cerisano G, et al. Predictors of reocclusion after successful drug-eluting stent-supported percutaneous coronary intervention of chronic total occlusion. J Am Coll Cardiol [Internet]. 2013 Feb 5 [cited 2022 Sep 13];61(5):545–50. Available from: https://pubmed.ncbi.nlm.nih.gov/23273395/

Galassi AR, Sianos G, Werner GS, Escaned J, Tomasello SD, Boukhris M, et al. Retrograde Recanalization of Chronic Total Occlusions in Europe. J Am Coll Cardiol [Internet]. 2015 Jun 9;65(22):2388 LP – 2400. Available from: http://www.onlinejacc.org/content/65/22/2388.abstract

Jones DA, Weerackody R, Rathod K, Behar J, Gallagher S, Knight CJ, et al. Successful recanalization of chronic total occlusions is associated with improved long-term survival. JACC Cardiovasc Interv [Internet]. 2012 Apr [cited 2022 Sep 14];5(4):380–8. Available from: https://pubmed.ncbi.nlm.nih.gov/22516393/

Fang HY, Lu SY, Lee WC, Lin YS, Cheng CI, Chen CJ, et al. The predictors of successful percutaneous coronary intervention in ostial left anterior descending artery chronic total occlusion. Catheterization and Cardiovascular Interventions [Internet]. 2014 Oct 1 [cited 2022 Sep 26];84(4):E30–7. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/ccd.25514

Banerjee S, Master RG, Peltz M, Willis B, Mohammed A, Little BB, et al. Influence of chronic total occlusions on coronary artery bypass graft surgical outcomes. J Card Surg. 2012 Nov;27(6):662–7.

Fefer P, Gannot S, Kochkina K, Maor E, Matetzky S, Raanani E, et al. Impact of coronary chronic total occlusions on long-term mortality in patients undergoing coronary artery bypass grafting. 2014 [cited 2021 Jul 2]; Available from: https://reference.medscape.com/medline/abstract/24618056

Farooq V, Serruys PW, Garcia-Garcia HM, Zhang Y, Bourantas C v., Holmes DR, et al. The negative impact of incomplete angiographic revascularization on clinical outcomes and its association with total occlusions: The SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) trial. J Am Coll Cardiol [Internet]. 2013 Jan 22 [cited 2021 Apr 12];61(3):282–94. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0735109712053727

Serruvs PW, Morice MCC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. New England Journal of Medicine [Internet]. 2009 Mar 5 [cited 2020 Oct 25];360(10):961–72. Available from: https://pubmed.ncbi.nlm.nih.gov/19228612/

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.