Surgical approach on Reccurent Retroperitoneal Liposarcoma with Involvement of Surrounding Organs
AJTES Vol 3, No 1, July 2019
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giant retroperitoneal liposarcoma
dedifferentiated liposarcoma

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Selmani, R., Karadzov, Z., Begovic, G., Rushiti, Q., Vrgovic, N., Gogovski, D., & Domazetovski, D. (2019). Surgical approach on Reccurent Retroperitoneal Liposarcoma with Involvement of Surrounding Organs. Albanian Journal of Trauma and Emergency Surgery, 3(1), 283-290.


Background: Retroperitoneal sarcomas are neoplasm that are only 0,3-3% of all solid tumors. Liposarcomas is most freguent soft tissue sarcomas in adults. Symptoms would only be detected if the liposarcoma presses on the surrounding organs.

Case presentation:  A 58-year-old woman presented with complaint of progressive abdominal distension, loss of appetite, malaise, constipation and weight loss of about 7 kg. Abdominal CT scanning showed the presence of a retroperitoneal tumor that occupies almost the entire right part of abdominal cavity. 16 months earlier, the patient was operated in another surgical facility due to liposarcom, derived from retroperitoneum (Histopathological finding: Poorly differentiated (G3) liposarcoma pleomorphic cell type). The patient was operated under the diagnosis of retroperitoneal liposarcoma.

Conclusions: Treatment of choice is radical surgical procedure including elimination of all the structures and organs involved by the tumour process - RO resection as a basic principle of surgical treatment.
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Neuhaus SJ, Barry P, Clark MA, Hayes AJ, Fisher C, et al (2005) Surgical management of primary and recurrent retroperitoneal liposarcoma. Br J Surg 92: 246-252

Antinori A, Antonacci V, Magistrelli P (2002) Giant retroperitoneal liposarcoma. Am J Surg 184: 56-57

Leao P, Vilaca S, Oliveira M, Falcao J (2012) :Giant recurrent retroperitoneal liposarcoma initially presenting as inguinal hernia: review of literature. Int J Surg Case Rep;3:103-106

Abbas Manji G, Singer S, Koff A, Schwartz GK.(2015): Application of molecular biology to individualize therapy for patients with liposarcoma. Am Soc Clin Oncol Educ Book. 2015:213-8

Dei Tos AP (2014). Liposarcomas: diagnostic pitfalls and new insights. Histopathology.; 64(1):38-52

Fletcher CD, Bridge JA, Hogendoorn P, Mertens F (2013) World Health Organization Classification of Tumours; Pathology and Genetics. Tumours of Soft Tissue and Bone. Lyon: IARC Press

Aimee M. Crago, Mark A. Dickson (2016). Liposarcoma:multimodality management and future targeted therapies. Surg Oncol Clin N Am. Oct; 25(4): 761–773

Mendenhall WM, Zlotecki RA, Hochwald SN, Hemming AW, Grobmyer SR, et al. (2005) Retroperitoneal soft tissue sarcoma. Cancer 104: 669-675

Evans HL. (1979):Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol. Dec; 3(6):507-23

Tateishi U, Hasegawa T, Beppu Y, Satake M, Moriyama N. (2003): Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features. J Comput Assist Tomogr. Sep-Oct; 27(5):799-804.

Bradley JC, Caplan R. (2002) Giant retroperitoneal sarcoma: a case report and review of the management of retroperitoneal sarcomas. Am Surg. Jan; 68(1):52-6.

Ki EY, Park ST, Park JS, Hur SY.(2012) A huge retroperitoneal liposarcoma: case report. Eur J Gynaecol Oncol. ;33(3):318-20.

Nijhuis PH, Sars PR, Plaat BE, Molenaar WM, Sluiter WJ, Hoekstra HJ. (2000): Clinico-pathological data and prognostic factors in completely resected AJCC stage I-III liposarcomas. Ann Surg Oncol. Aug; 7(7):535-43.

Singer S, Antonescu CR, Riedel E, Brennan MF(2003): Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg;238:52–65.

McCallum OJ, Bruke JJ II, Childs AJ, Ferro A, Gallup DG (2006): Retroperitoneal liposarcoma weighing over one hundred pounds with review of the literature. Gynecol Oncol;103:1152–1154. 7.

Milone M, Pezzullo LS, Salvatore G, Pezzullo MG, Leongito M, Esposito I, Milone F. (2011): Management of high-grade retroperitoneal liposarcomas: personal experience. Updates Surg. Jun; 63(2):119-24.

Daldoul S, Zahaf B, Hamdi Ghassen E, Marwa B, Yacine Ben S and Mounir Ben M.(2017): Retro-Peritoneal Liposarcoma: Diagnostic Difficulties and Therapeutic Attitudes. Surgery Curr Res, 7:5

Bautista N, Su W, O'Connell TX (2000). Retroperitoneal soft-tissue sarcomas: prognosis and treatment of primary and recurrent disease. Am Surg Sep; 66(9):832-6.

Selmani R, Begovic G, Janevski V, Rushiti Q, Karpuzi A.(2011) Giant retroperitoneal liposarcoma: а case report. Contributions, Sec. Biol. Med. Sci, MASA, XXXII, 1,p. 323-332

In-Hwan Kim, Hyun-Dong Chae.(2017) Giant Dedifferentiated Liposarcoma of the Retroperitoneum. J Gastrointest Dig Syst ,7:1.

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